Thermo Fisher Scientific CD123 Monoclonal Antibody (6H6), APC, eBioscience
인간 CD123(IL-3 수용체 α체인)을 인식하는 6H6 클론 단일클론 항체로 APC 형광체가 결합되어 있습니다. 유세포 분석(Flow Cytometry)에 최적화되어 있으며, 고순도 친화 크로마토그래피 정제. 4°C 암소 보관, 연구용 전용.
- 카탈로그번호
- 17-1239-42
- 판매단위
- pk
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Thermo Fisher Scientific CD123 Monoclonal Antibody (6H6), APC, eBioscience™
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 2 publications |
| Flow Cytometry (Flow) | 5 µL (0.25 µg)/test | View 7 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6H6 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11039535 |
Available Conjugate Formats
- Unconjugated
- Alexa Fluor 532
- Alexa Fluor 700
- APC-eFluor 780
- Biotin
- Brilliant UV 395 / 615 / 661 / 737 / 805
- Brilliant Violet 480 / 786
- eFluor 450
- FITC
- NovaFluor Blue 510
- PE / PE-Cyanine5 / PE-Cyanine7 / PE-eFluor 610
- PerCP-Cyanine5.5
- Super Bright 436 / 600 / 645 / 702
- Request custom conjugation
Product Specific Information
The 6H6 monoclonal antibody reacts with human CD123, the alpha chain of the IL-3 receptor. This 60–70 kDa transmembrane protein binds IL-3 with low affinity alone, and with CD131 (common beta chain) forms a high-affinity receptor complex. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, and megakaryocytes.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated for flow cytometry on normal human peripheral blood cells; use at 5 µL (0.25 µg) per test (100 µL final volume).
- Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
IL-3Ra (Interleukin-3 receptor subunit alpha) is part of the type I cytokine receptor family and forms a heterodimer with the common beta (CDw131) subunit. It mediates IL-3 signal transduction, where heterodimerization is induced by IL-3. IL-3Ra is overexpressed on acute myeloid leukemia (AML) blasts compared with normal hematopoietic cells, making it a potential target for novel therapeutic approaches.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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