Thermo Fisher Scientific GEMIN8 Monoclonal Antibody (OTI4B12), TrueMAB
인간 GEMIN8 단백질을 인식하는 마우스 단클론 항체로 Western blot에 최적화됨. 무보존제, 동결건조 형태로 제공되며 재구성 후 1 mg/mL 농도로 사용 가능. SMN 복합체 관련 연구에 적합한 고품질 TrueMAB 항체.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B12 |
| Immunogen | Full length human recombinant protein of human GEMIN8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional round of desalting using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), essential components of the spliceosome. It is crucial for pre-mRNA splicing in cells.
Most spliceosomal snRNPs contain common Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG) that form a heptameric ring on the Sm site of small nuclear RNA.
In the cytosol, Sm proteins are initially trapped in an inactive 6S pICln-Sm complex by CLNS1A, which regulates snRNP assembly. The SMN complex dissociates CLNS1A, allowing Sm proteins to form the active SMN-Sm complex and be transported to the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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