Thermo Fisher Scientific GEMIN8 Monoclonal Antibody (OTI1A8), TrueMAB
GEMIN8 단백질을 인식하는 마우스 단클론 항체로 Western blot에 적합합니다. 인간 유래 단백질을 면역원으로 제작되었으며, 동결건조 형태로 제공됩니다. 친화 크로마토그래피로 정제되었고, 보존제가 포함되지 않습니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A8 |
| Immunogen | Full length human recombinant protein of human GEMIN8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The SMN complex acts as a catalyst in the assembly of small nuclear ribonucleoproteins (snRNPs), essential components of the spliceosome. It plays a key role in pre-mRNA splicing.
Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG) form a heptameric ring on the Sm site of small nuclear RNA, constituting the core snRNP.
In the cytosol, Sm proteins are sequestered in an inactive 6S pICln-Sm complex by CLNS1A. The SMN complex mediates the release of Sm proteins from CLNS1A and their assembly into SMN-Sm complexes, leading to snRNP formation and nuclear transport.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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