Thermo Fisher Scientific Ubiquitin +1 Monoclonal Antibody (40B3)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunoprecipitation (IP)

1-2 µL

-

Product Specifications

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

40B3

Immunogen

Synthetic peptide, KLH coupled, corresponding to the C-terminal residues of human Ubiquitin +1 protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Ubiquitin +1,uniProtId:P0CG47-1,ncbiNodeId:9606,antigenRange:229,antigenLength:229,antigenImageFileName:LF-MA0087_Ubiquitin_+1_P0CG47-1_House_mouse.svg,antigenImageFileNamePDP:LF-MA0087_Ubiquitin_+1_P0CG47-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_1088160

Product Specific Information

A suggested positive control for this product is Bosc23 cells transfected with GFP-Ub+1.

Target Information

Ubiquitin+1 (Ub+1) is a novel mutant form of ubiquitin that can be produced through a process known as molecular frameshift. Ub+1 can be polyubiquitinated to produce aberrant polyubiquitin chains that inhibit the 26S proteasome. Especially ub+1 is accumulated in aggregates containing amyloid-beta and phosphorylated-tau. Elevated expression of Ub+1 mRNA and protein has been observed in the brains of patients with Alzheimer`s disease. Also ub +1 acts as an aggravating factor in polyglutamine-induced neurodegeneration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.