Thermo Fisher Scientific Ubiquitin +1 Monoclonal Antibody (40B3)
Ubiquitin +1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB 및 IP에 적합. 인간 Ubiquitin +1 C-말단 합성 펩타이드로 면역화됨. 알츠하이머 및 신경퇴행 연구에 유용. 액상 형태로 -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunoprecipitation (IP)
- Tested Dilution: 1–2 µL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 40B3 |
| Immunogen | Synthetic peptide, KLH coupled, corresponding to the C-terminal residues of human Ubiquitin +1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_1088160 |
Product Specific Information
A suggested positive control for this product is Bosc23 cells transfected with GFP-Ub+1.
Target Information
Ubiquitin+1 (Ub+1) is a novel mutant form of ubiquitin produced through a molecular frameshift process. Ub+1 can be polyubiquitinated to produce aberrant polyubiquitin chains that inhibit the 26S proteasome. Ub+1 accumulates in aggregates containing amyloid-beta and phosphorylated tau. Elevated expression of Ub+1 mRNA and protein has been observed in the brains of Alzheimer’s disease patients. Ub+1 acts as an aggravating factor in polyglutamine-induced neurodegeneration.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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