Thermo Fisher Scientific CD47 Chimeric Recombinant Rabbit Monoclonal Antibody (h4C1)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody binds the FG loop of human CD47, which interacts with SIRP alpha and other known CD47/SIRP alpha-blocking monoclonal antibodies. CD47 is broadly distributed on normal adult tissues and ovarian tumors, and is abundant in certain epithelia and brain regions. Integrin-associated protein (IAP) acts as an adhesion receptor for THBS1 on platelets and modulates integrins. It plays a role in memory formation and synaptic plasticity in the hippocampus, and acts as a receptor for SIRPA, preventing maturation of immature dendritic cells and inhibiting cytokine production by mature dendritic cells.

Target Information

CD47 (integrin-associated protein, IAP) is a ubiquitously expressed transmembrane glycoprotein that interacts with several integrins and regulates their functions. Engagement of CD47 modulates signaling pathways, including activation of heterotrimeric G proteins and increases intracellular calcium concentration upon cell adhesion to extracellular matrix. CD47 serves as a receptor for the C-terminal cell binding domain of thrombospondin and may play a role in membrane transport and signal transduction. It is broadly distributed across tissues but reduced on Rh erythrocytes. CD47 acts as a ligand for CD172a (SIRP alpha), an immune inhibitory receptor on macrophages, preventing phagocytosis of CD47-positive cells. The CD47-CD172a system influences cell migration, B cell adhesion, T cell activation, chondrocyte mechanosensing, and neuronal development, being abundant in synapse-rich brain and retinal regions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.