Thermo Fisher Scientific IRE1 Polyclonal Antibody
Thermo Fisher Scientific의 IRE1 Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가지며 Western blot, ELISA, Immunoprecipitation에 적합합니다. 합성 펩타이드 면역원으로 제작된 비결합 폴리클로날 항체로, 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- IRE1A-101AP
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IRE1 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to unique amino acid sequence within amino acid region 900–1000 on human IRE1A protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ERN1 serine/threonine kinase, also known as endoplasmic reticulum to nucleus signaling 1 (IRE1), is a human homologue of the yeast Ire1 gene product. It possesses intrinsic kinase and endoribonuclease activity and plays a key role in ER-based stress signaling. ERN1 controls IRE1 proteolysis in mammalian cells and is essential for fetal viability in extraembryonic cells. IRE1 acts as a sensor of unfolded proteins in the ER, initiating the unfolded protein response by splicing XBP1 mRNA, converting it into a potent transcriptional activator. Null mutants are viable but essential under stress conditions that cause unfolded proteins to accumulate in the ER. Depletion of IRE1p through dominant negative expression leads to apoptosis under such stress conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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