Thermo Fisher Scientific UBE2D1 Recombinant Rabbit Monoclonal Antibody (8E6O0)
Thermo Fisher Scientific의 UBE2D1 recombinant rabbit monoclonal antibody (clone 8E6O0)은 인간, 마우스, 랫트에 반응하며, IHC(P) 및 ELISA에 적합합니다. HEK293 세포에서 발현된 단일클론 항체로, Protein A로 정제되어 높은 특이성과 재현성을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 8E6O0 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 50–147 of human SFT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
FFLTVHFPTD YPFKPPKIAF TTKIYHPNIN SNGSICLDIL RSQWSPALTV SKVLLSICSL LCDPNPDDPL VPDIAQIYKS DKEKYNRHAR EWTQKYAM
Target Information
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s).
UBE2D1 encodes an E2 ubiquitin-conjugating enzyme closely related to a stimulator of iron transport (SFT) and is up-regulated in hereditary hemochromatosis. It also participates in the ubiquitination of tumor-suppressor protein p53 and hypoxia-inducible transcription factor HIF1α by interacting with E1 and E3 enzymes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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