Thermo Fisher Scientific ABCA1 Recombinant Rabbit Monoclonal Antibody (10G8Z7)
ABCA1 단백질을 인식하는 토끼 단클론 항체로, 인간·마우스·랫트 시료에 반응합니다. ICC/IF 및 ELISA에 사용 가능하며, 고순도의 Protein A 정제 항체입니다. 재조합 형식으로 높은 재현성과 특이성을 제공합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10G8Z7 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1170–1350 of human ABCA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.98 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
DHESDTLTID VSAISNLIRK HVSEARLVED IGHELTYVLP YEAAKEGAFV ELFHEIDDRL SDLGISSYGI SETTLEEIFL KVAEESGVDA ETSDGTLPAR RNRRAFGDKQ SCLRPFTEDD AADPNDSDID PESRETDLLS GMDGKGSYQV KGWKLTQQQF VALLWKRLLI ARRSRKGFFA Q
Target Information
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD).
TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester deposition in the reticulo-endothelial system, and deviations in cellular lipid trafficking.
ABCA1 mediates the apo-A1-associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex and is regulated by cholesterol flux.
Regulation of cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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