Thermo Fisher Scientific ABCA1 Recombinant Rabbit Monoclonal Antibody (10G8Z7)

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

10G8Z7

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1170-1350 of human ABCA1. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ABCA1,uniProtId:O95477-1,ncbiNodeId:9606,antigenRange:1170-1350,antigenLength:2261,antigenImageFileName:MA5-55376_ABCA1_O95477-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55376_ABCA1_O95477-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.98 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: DHESDTLTID VSAISNLIRK HVSEARLVED IGHELTYVLP YEAAKEGAFV ELFHEIDDRL SDLGISSYGI SETTLEEIFL KVAEESGVDA ETSDGTLPAR RNRRAFGDKQ SCLRPFTEDD AADPNDSDID PESRETDLLS GMDGKGSYQV KGWKLTQQQF VALLWKRLLI ARRSRKGFFA Q

Target Information

Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.