Thermo Fisher Scientific USP28 Polyclonal Antibody
Thermo Fisher Scientific의 USP28 폴리클로날 항체는 인간 USP28 단백질을 인식하며 Western blot과 Flow cytometry에 적합합니다. 항원 친화 크로마토그래피로 정제된 고순도 항체로, 핵 내 USP28 검출에 활용됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific USP28 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within human USP28 aa 550–700 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2913240 |
Product Specific Information
- Positive Control: K562, A549, Daudi
- Subcellular Location: Nucleus
Target Information
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. Attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity.
An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families:
- Ubiquitin C-terminal hydrolases
- Ubiquitin-specific processing proteases (USPs)
- OTU-domain ubiquitin-aldehyde-binding proteins
- Jab1/Pad1/MPN-domain-containing metallo-enzymes
Among these families, USPs are the most widespread deubiquitinating enzymes. They release ubiquitin from conjugated proteins and possess conserved catalytic domains containing Cys and His boxes with variable terminal extensions involved in substrate recognition and protein interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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