Thermo Fisher Scientific IL1RA Monoclonal Antibody (35730 (49/20))

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

-

ELISA (ELISA)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

35730 (49/20)

Immunogen

Recombinant peptide corresponding to the extracellular domain of human CD121a expressed in insect cell line Sf21

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

affinity chromatography

Storage buffer

PBS, pH 7.2, with <5% trehalose

Contains

0.09% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2124907

Product Specific Information

This antibody does not react with rmIL-1 RI or rhIL-1 RII in either Western blot or ELISA applications.

Mouse anti human CD121a, clone 35730, recognizes interleukin-1 receptor type 1 (IL1R1). IL1RA/CD121a is widely expressed in a number of cell types including T cells and fibroblasts (Sims et al.)and is involved in the activation of NF-kappa-B (Slack et al.).

Target Information

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.