Thermo Fisher Scientific BAIAP2 Polyclonal Antibody
BAIAP2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, ICC/IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, PBS + 50% 글리세롤 용액 형태로 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 362–521 of human BAIAP2 (NP_059344.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.97 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901640 |
Product Specific Information
- Positive Samples: A-549, K-562, SW620, 293T
- Immunogen sequence:
PRSSSMAAGL ERNGRMRVKA IFSHAAGDNS TLLSFKEGDL ITLLVPEARD GWHYGESEKT KMRGWFPFSY TRVLDSDGSD RLHMSLQQGK SSSTGNLLDK DDLAIPPPDY GAASRAFPAQ TASGFKQRPY SVAVPAFSQG LDDYGARSMS SGSGTLVSTV
Target Information
The protein encoded by this gene functions as a brain-specific angiogenesis inhibitor (BAI1)-binding adaptor protein, linking membrane-bound G-proteins to cytoplasmic effector proteins. It serves as an insulin receptor tyrosine kinase substrate, suggesting a role for insulin in the central nervous system.
This protein interacts with Rho small G protein effectors, contributing to stress fiber formation and cytokinesis. It is involved in lamellipodia and filopodia formation in motile cells and may influence neuronal growth-cone guidance.
Additionally, it interacts with the dentatorubral-pallidoluysian atrophy gene, associated with an autosomal dominant neurodegenerative disease. Alternative splicing produces multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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