Thermo Fisher Scientific Blood Group Antigen H Type 2 (CD173) Monoclonal Antibody (A46-B/B10)

Thermo Fisher Scientific Blood Group Antigen H Type 2 (CD173) Monoclonal Antibody (A46-B/B10)

Applications and Tested Dilution

Product Specifications

Target Information

The H antigen is a precursor to the ABO blood group antigens, present in people of all common blood types. The Bombay phenotype (hh) does not express antigen H on red blood cells and therefore lacks A or B antigens, similar to the O blood group. However, unlike the O group, the H antigen is absent, leading to production of isoantibodies to antigen H as well as A and B antigens.

If individuals with the Bombay phenotype receive blood from someone with O blood group, anti-H antibodies will bind to the H antigen on donor red blood cells and cause complement-mediated lysis. Thus, they can receive blood only from other hh donors but can donate as though they were type O.

The production of the H antigen, or its deficiency in the Bombay phenotype, is controlled at the H locus on chromosome 19. This locus encodes a fucosyltransferase responsible for producing the H antigen on RBCs. The H antigen is a carbohydrate sequence primarily linked to protein, with a minor fraction attached to a ceramide moiety.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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