Thermo Fisher Scientific VISTA Polyclonal Antibody
Thermo Fisher Scientific의 VISTA Polyclonal Antibody는 마우스 유래 단백질을 인식하는 Sheep IgG 항체로, Western blot, ICC/IF, Flow cytometry에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 5% 트레할로스로 보관됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–15 µg/mL |
| Flow Cytometry (Flow) | 0.25 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse VISTA/B7-H5/PD-1H (Phe33–Ala191) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606501 |
Product Specific Information
- In direct ELISAs, approximately 25% cross-reactivity with recombinant human VISTA/B7-H5/PD-1H is observed.
- Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene.
Although VISTA bears sequence homology to PD-L1, it has a distinct expression pattern. In both mice and humans, VISTA is predominantly expressed on hematopoietic cells, with the highest levels on myeloid cells and lower levels on T cells, and is generally absent on B cells.
VISTA expressed by antigen-presenting cells has been shown to suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a promising target for cancer immunotherapy. Reported ligands of VISTA include CD28H, VSIG-3, and VSIG-8.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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