Thermo Fisher Scientific Neuropilin 1 Polyclonal Antibody
Neuropilin 1 단백질을 인식하는 Thermo Fisher Scientific의 Goat Polyclonal Antibody. WB, IHC, ICC, Flow 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 고순도 제품. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Neuropilin 1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3–25 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 3–15 µg/mL | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 2.5 µg per million cells | - |
| Neutralization (Neu) | Assay-Dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant rat Neuropilin-1 (Phe22–Ala810, Lys811Arg; Ser829–Asp854) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608228 |
Product Specific Information
- In direct ELISAs, approximately 25% cross-reactivity with recombinant human Neuropilin-1 is observed.
- Less than 1% cross-reactivity with recombinant human, mouse, and rat Neuropilin-2.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level <0.10 EU per 1 µg of antibody (LAL method).
Target Information
Neuropilin 1 is a 923-amino-acid membrane-bound coreceptor belonging to the neuropilin family.
It contains two CUB domains, two F5/8 type C domains, and a MAM domain.
Neuropilin 1 forms heterodimers with Neuropilin 2 (NRP2) and binds to plexin (PLXNB1) to form semaphorin receptors.
Mainly expressed in the nervous system, it plays roles in:
- Cardiovascular system development
- Angiogenesis
- Axon guidance
- Neuronal circuit formation
- Cell survival and migration
- Organogenesis outside the nervous system
It functions as a receptor for semaphorins and VEGF, regulating VEGF-induced angiogenesis.
Neuropilin 1 may be associated with aggressive prostate and breast cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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