Thermo Fisher Scientific Phospho-Chimaerin beta 2 (Ser171) Polyclonal Antibody
Phospho-Chimaerin beta 2 (Ser171) 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot, ELISA, IP에 적합. Human, Mouse, Rat 반응성. 고순도 친화 크로마토그래피 정제. 연구용으로만 사용.
- 카탈로그번호
- PCHIM-140AP
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Phospho-Chimaerin beta 2 (Ser171) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phosphorylated synthetic peptide corresponding to unique amino acid sequence on beta 2 Chimaerin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain, and an SH2 domain. It possesses GTPase-activating protein activity regulated by phospholipid binding. Binding of diacylglycerol (DAG) induces translocation from the cytosol to the Golgi apparatus membrane. The protein influences proliferation and migration of smooth muscle cells.
Decreased expression is associated with high-grade gliomas and breast tumors, whereas increased expression is linked to lymphomas. Mutations have been associated with schizophrenia in men. Alternate splice variants encoding different isoforms have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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