Thermo Fisher Scientific NOTCH1 Monoclonal Antibody (mN1A), FITC

Thermo Fisher Scientific NOTCH1 Monoclonal Antibody (mN1A), FITC

Applications

• Flow Cytometry (Flow)

Tested Dilution: Neat-1:10
Publications: [참고 문헌 링크 없음]

Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Product Specific Information

Membrane permeabilization is required for flow cytometry applications.
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.

Mouse anti-Mouse Notch1 antibody, clone mN1A recognizes Notch1, one of the four major transmembrane receptors (Notch1–4) of the Notch signaling pathway, which is activated through binding to DSL domain-containing membrane-bound specific ligands.

Target Information

The notch gene family encodes transmembrane proteins with multiple cysteine-rich EGF-like repeats in the extracellular region.
Four notch genes have been described in mammals: Notch1, Notch2, Notch3, and Notch4 (Int-3), which are involved in differentiation of the nervous system and other structures.
EGF-like proteins Delta and Serrate act as ligands of Notch1.
Mature Notch proteins are heterodimeric receptors derived from cleavage of Notch pre-proteins into:

• Extracellular subunit (NEC) containing multiple EGF-like repeats
• Transmembrane subunit (Ntm) including intracellular regions

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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