Thermo Fisher Scientific DC-SIGN Monoclonal Antibody (MR-1)

Applications and Tested Dilutions

Product Specifications

Additional Formats

• FITC Conjugate (MA5-16867)
• Request custom conjugation

Product Specific Information

This product is a low-endotoxin, preservative-free formulation.
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.

Target Information

The DC-SIGN (CD209) gene encodes a transmembrane receptor expressed on the surface of dendritic cells and macrophages. It plays a key role in the innate immune system by recognizing a wide range of pathogens, including parasites and viruses.
The protein contains three main domains:

• N-terminal transmembrane domain
• Tandem-repeat neck domain
• C-type lectin carbohydrate recognition domain

The extracellular region functions as both a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on microbial and endogenous cell surfaces.
The neck region mediates homo-oligomerization, enabling high-avidity binding to multivalent ligands.
Rare variations in the 23 amino acid repeats within the neck domain can significantly affect ligand-binding ability.
DC-SIGN is closely related to L-SIGN (GeneID 10332), with differences in ligand-binding properties and tissue distribution.
Alternative splicing results in multiple variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.