Thermo Fisher Scientific DC-SIGN Monoclonal Antibody (MR-1), FITC
인간 DC-SIGN(CD209)을 인식하는 MR-1 클론 단일클론 항체로, FITC 형광 표지되어 유세포분석(Flow Cytometry)에 적합합니다. 단백질 A로 정제되었으며 PBS/BSA 버퍼에 보존됩니다. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: Neat-1:5
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MR-1 |
| Immunogen | Immature myeloid monocyte-derived dendritic cells (MDDCs) |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538345 |
Additional Formats
- Unconjugated
- Request custom conjugation
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
Mouse anti-Human CD209 antibody, clone MR-1 recognizes human DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), an approximately 45 kDa C-type lectin that binds ICAM-3, also known as CD209.
CD209 is primarily expressed on immature dendritic cells in peripheral tissues and on immature myeloid monocyte-derived DCs in vitro.
Target Information
This gene encodes a transmembrane receptor referred to as DC-SIGN (CD209), expressed on dendritic cells and macrophages.
It plays a role in the innate immune system, recognizing diverse pathogens from parasites to viruses.
The protein consists of:
- N-terminal transmembrane domain
- Tandem-repeat neck domain
- C-type lectin carbohydrate recognition domain
The extracellular region functions as both a pathogen recognition receptor and a cell adhesion receptor.
The neck domain enables homo-oligomerization, enhancing multivalent ligand binding.
Variations in the neck domain repeat number can affect ligand binding ability.
DC-SIGN is closely related to L-SIGN (GeneID 10332), differing in ligand-binding properties and distribution.
Alternative splicing produces multiple variants.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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