Thermo Fisher Scientific IRF4 Polyclonal Antibody
IRF4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 ELISA에 사용 가능하며, 인간 및 마우스 시료에 반응. 액상 형태로 제공되며, 친화 크로마토그래피로 정제. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 150–350 of human IRF4 (NP_0024512) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.57 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804156 |
Product Specific Information
Immunogen sequence:
HPYTMTTPYP SLPAQQVHNY MMPPLDRSWR DYVPDQPHPE IPYQCPMTFG PRGHHWQGPA CENGCQVTGT FYACAPPESQ APGVPTEPSI RSAEALAFSD CRLHICLYYR EILVKELTTS SPEGCRISHG HTYDASNLDQ VLFPYPEDNG QRKNIEKLLS HLERGVVLWM APDGLYAKRL CQSRIYWDGP LALCNDRPNK L
Positive Samples: Mouse spleen, Mouse lung, Rat spleen, Rat lung, Rat thymus
Cellular Location: Nucleus
Target Information
The IRF (interferon regulatory factor) family of transcription factors are characterized by a unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in regulating interferons in response to viral infection and in the regulation of interferon-inducible genes.
IRF4 is lymphocyte-specific and negatively regulates toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems.
A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be associated with multiple myeloma. Alternatively spliced transcript variants have been identified.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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