Thermo Fisher Scientific NEDD4 Polyclonal Antibody
Rabbit polyclonal antibody against human NEDD4 protein. Validated for WB, IHC-P, and ELISA. Affinity purified, supplied in PBS with 50% glycerol. Suitable for detecting NEDD4 in various human cell lines and research applications.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein corresponding to amino acids 160–460 of human NEDD4 (NP_9406822) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804161 |
Product Specific Information
Immunogen sequence:
GSYSSNGSDF GSCASITSGG SYTNSVISDS SSYTFPPSDD TFLGGNLPSD STSNRSVPNR NTTPCEIFSR STSTDPFVQD DLEHGLEIMK LPVSRNTKIP LKRYSSLVIF PRSPSTTRPT SPTSLCTLLS KGSYQTSHQF IISPSEIAHN EDGTSAKGFL STAVNGLRLS KTICTPGEVR DIRPLHRKGS LQKKIVLSNN TPRQTVCEKS SEGYSCVSVH FTQRKAATLD CETTNGDCKP EMSEIKLNSD SEYIKLMHRT SACLPSSQNV DCQININGEL ERPHSQMNKN HGILRRSISL G
Positive Samples: U-251MG, HeLa, Jurkat, A-549, SKOV3
Cellular Location: Cell membrane, Cytoplasm, Peripheral membrane protein
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It participates in the degradation of VEGFR-2/KDFR independently of ubiquitin-ligase activity and acts as a potential proto-oncogene by negatively regulating PTEN via ubiquitination. NEDD4 is involved in viral budding and regulates epithelial Na⁺ channels, contributing to arterial hypertension. It localizes to the sarcolemmal region of muscle fibers, and its overexpression is associated with muscle denervation and decreased Notch1 expression, functioning as a down-regulator of Notch-1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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