Thermo Fisher Scientific DISC1 Recombinant Superclonal Antibody (4HCLC)
DISC1 단백질을 인식하는 Thermo Fisher Scientific의 재조합 Superclonal™ 항체로, 인간·마우스·랫트 시료에 반응합니다. WB, IHC, ICC 등 다양한 응용에 적합하며, 높은 민감도와 재현성을 제공합니다. 단백질 A 정제, 액상 형태로 안정적 보관이 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 | - |
| Immunocytochemistry (ICC/IF) | 2–4 µg | - |
| Miscellaneous PubMed (Misc) | - | View publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Superclonal |
| Type | Antibody |
| Clone | 4HCLC |
| Immunogen | Peptide corresponding to amino acids 419–428 of human DISC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532621 |
Product Specific Information
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They consist of multiple recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.
These antibodies recognize multiple epitope sites, providing higher detection sensitivity for low-abundance targets, while maintaining reproducibility across lots.
Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody” with unchanged performance.
Target Information
DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein interacting with various centrosome and cytoskeletal proteins. It plays a role in neuronal migration, neurite architecture, and intracellular transport.
DISC1 is expressed in the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum, and paraventricular hypothalamus.
Loss of DISC1 function is associated with schizophrenia due to chromosomal translocations.
DISC1 interacts with proteins such as MIPT3, MAP1A, NUDEL, alpha-actinin 2, beta 4-spectrin, ATF-4, and ATF-5, implicating it in intracellular transport and neuronal development.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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