Thermo Fisher Scientific SMAD1 Recombinant Superclonal Antibody (12HCLC)

Applications

• Western Blot (WB): 1–3 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with equine, mouse, rabbit, and rat based on sequence homology.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They consist of a selection of multiple recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.

While functionally similar to polyclonal antibodies—recognizing multiple epitope sites and providing higher detection sensitivity—a recombinant rabbit Superclonal™ antibody has a defined mixture of light and heavy chains, enabling consistent lot-to-lot production and eliminating biological variability.

Note: Formerly called “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”. The product and performance remain unchanged.

Target Information

The SMAD1 protein belongs to the SMAD family, homologous to the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins act as signal transducers and transcriptional modulators mediating multiple signaling pathways.

SMAD1 mediates bone morphogenetic protein (BMP) signaling, which regulates cell growth, apoptosis, morphogenesis, development, and immune responses. Upon BMP ligand binding, SMAD1 is phosphorylated and activated by BMP receptor kinase, forming a complex with SMAD4 for transcriptional regulation. SMAD1 is also targeted by SMAD-specific E3 ubiquitin ligases (SMURF1, SMURF2) for ubiquitination and proteasomal degradation.

Alternatively spliced transcript variants encoding the same protein have been observed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.