Thermo Fisher Scientific 53BP1 Polyclonal Antibody, HRP
인간 및 생쥐 시료에 반응하는 HRP 결합 53BP1 폴리클로날 항체입니다. Western blot과 IHC(파라핀) 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 암 억제 및 DNA 손상 반응 연구에 활용됩니다.
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Thermo Fisher Scientific 53BP1 Polyclonal Antibody, HRP
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a portion of human 53BP1 encoded in exon 11, 12, and 19 (Uniprot: Q12888, aa 12–19) |
| Conjugate | HRP |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_11155176 |
Product Specific Information
This antibody reacts with human samples in Western blot and ICC applications, and with mouse samples in ICC applications.
Target Information
53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to double-strand breaks. It is involved in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and contributes to genomic stability by participating in DNA repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-22793_53BP1_Q12888-1_Rabbit_PDP.jpeg, PA5-22793_53BP1_Q12888-1_Rabbit.svg)
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배송/결제/교환/반품 안내
배송 정보
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