Thermo Fisher Scientific 53BP1 Polyclonal Antibody, HRP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:10,000

-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-Dependent

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a portion of human 53BP1 encoded in exon 11, 12 and 19 [Uniprot: Q12888] (aa 12-19). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:53BP1,uniProtId:Q12888-1,ncbiNodeId:9606,antigenRange:12-19,antigenLength:1972,antigenImageFileName:PA5-22793_53BP1_Q12888-1_Rabbit.svg,antigenImageFileNamePDP:PA5-22793_53BP1_Q12888-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

HRP HRP HRP

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

no preservative

Storage conditions

4° C, store in dark

Shipping conditions

Wet ice

RRID

AB_11155176

Product Specific Information

This antibody reacts with Human samples in Western blot and ICC applications, and with Mouse in ICC applications.

Target Information

53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.