Thermo Fisher Scientific 53BP1 Polyclonal Antibody, HRP
인간 및 생쥐 시료에 반응하는 HRP 결합 53BP1 폴리클로날 항체입니다. Western blot과 IHC(파라핀) 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 암 억제 및 DNA 손상 반응 연구에 활용됩니다.
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Thermo Fisher Scientific 53BP1 Polyclonal Antibody, HRP
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a portion of human 53BP1 encoded in exon 11, 12, and 19 (Uniprot: Q12888, aa 12–19) |
| Conjugate | HRP |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_11155176 |
Product Specific Information
This antibody reacts with human samples in Western blot and ICC applications, and with mouse samples in ICC applications.
Target Information
53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to double-strand breaks. It is involved in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and contributes to genomic stability by participating in DNA repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-22793_53BP1_Q12888-1_Rabbit_PDP.jpeg, PA5-22793_53BP1_Q12888-1_Rabbit.svg)
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