Thermo Fisher Scientific CD304 (Neuropilin-1) Recombinant Rabbit Monoclonal Antibody (ST05-30)
CD304 (Neuropilin-1) 단백질을 표적하는 재조합 토끼 단클론 항체로, 높은 특이성과 민감도를 제공합니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며, 로트 간 일관성과 동물 유래 성분이 없는 포뮬레이션을 제공합니다. 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:5,000
- View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ST05-30 |
| Immunogen | Synthetic peptide within Human Neuropilin-1 (aa 881–923) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809467 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal production candidates.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
Neuropilin 1 (CD304) is a 923-amino acid membrane-bound coreceptor belonging to the neuropilin family. It contains two CUB domains, two F5/8 type C domains, and a MAM domain.
Neuropilin 1 forms heterodimers with Neuropilin 2 (NRP2) and binds to plexin (PLXNB1) to form semaphorin receptors.
It is predominantly expressed in the nervous system and plays roles in:
- Cardiovascular system development
- Angiogenesis
- Axon guidance and neuronal circuit formation
- Cell survival and migration
- Organogenesis beyond the nervous system
Neuropilin 1 acts as a receptor for both semaphorins and VEGF, regulating VEGF-induced angiogenesis. It may be involved in aggressive prostate carcinoma and breast cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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