Thermo Fisher Scientific GRK2 Recombinant Rabbit Monoclonal Antibody (ST05-60)
GRK2 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, Western blot 및 IHC(P) 검증 완료. 높은 특이성과 재현성을 제공하며, Protein A로 정제된 액상 형태. 인간, 생쥐, 랫트 반응성. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ST05-60 |
| Immunogen | Synthetic peptide within Human GRK2 aa 640–689 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809469 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The specific antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select the best candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to the large rabbit immune repertoire
Target Information
ADRBK1 (GRK2) is a serine/threonine kinase that phosphorylates G protein-coupled receptors (GPCRs). GRK2 (83 kDa) is one of six identified GRKs and is ubiquitously expressed in mammals.
Upon ligand binding and G protein activation, GPCRs are phosphorylated by GRKs, leading to receptor internalization regulated by beta-arrestin-1 and activation of the Ras–Raf–ERK1/2 signaling pathway.
GRK2 activity is regulated by phosphorylation (PKC, Src, ERK1/2) and protein interactions. ERK phosphorylates GRK2 on serine 670, providing a negative feedback mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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