Thermo Fisher Scientific LDLR Monoclonal Antibody (OTI8D12), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Flow Cytometry (Flow)

• Tested Dilution: Assay-Dependent

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of ~1 mg/mL.
• For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL binds at the cell membrane and is internalized into lysosomes, where the protein is degraded and cholesterol becomes available for repression of HMG CoA reductase, the rate-limiting enzyme in cholesterol synthesis. Mutations in the LDL-R gene cause familial hypercholesterolemia. LDL-R also acts as an entry factor for Hepatitis C virus along with SCARB1, CLDN1, and CD81. At least three isoforms of LDL-R are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.