Thermo Fisher Scientific WAVE2 Polyclonal Antibody
WAVE2 단백질을 특이적으로 인식하는 토끼 폴리클로날 항체. Western blot과 면역세포염색에 적합. 인간, 마우스, 랫트 시료 반응. 항원 친화 크로마토그래피로 정제된 고순도 제품. 세포 골격 재구성 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide (coupled to KLH) corresponding to amino acid residues in the central region of human WAVE2. This sequence has high homology with similar regions in rat and mouse WAVE2, and has low homology to similar regions in WAVE1 and WAVE3. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2943023 |
Product Specific Information
The antibody detects an 84 kDa protein corresponding to the molecular mass of WAVE2 on SDS-PAGE immunoblots of human K562, mouse C2C12, and rat PC12 cells.
Target Information
WASP (Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 implicated in actin polymerization and cytoskeletal organization. The WASP family also includes VASP and Mena, which accumulate at focal adhesions and regulate actin cytoskeleton dynamics.
WAVE proteins, related to the WASP family, mediate actin reorganization downstream of the Rho family of small GTPases. WAVE1 and WAVE2 regulate membrane ruffling by inducing actin filament clusters in response to Rac activation.
These proteins cooperate with the Arp2/3 complex to promote actin filament formation. WAVE1 (also known as SCAR) is mainly expressed in the brain, while WAVE2 is widely expressed, particularly in peripheral blood leukocytes. WAVE3 forms a multiprotein complex linking receptor kinases and actin. All family members bind actin through a C-terminal verprolin homology domain, transducing signals that alter cell shape, motility, or function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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