Thermo Fisher Scientific CD127 Polyclonal Antibody
Thermo Fisher Scientific의 CD127 Polyclonal Antibody는 인간 IL-7Rα/CD127을 표적으로 하는 염소 유래 다클론 항체입니다. Western blot과 유세포 분석에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용되며, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 0.25 µg per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human IL-7 R alpha/CD127 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609353 |
Product Specific Information
- In direct ELISAs, less than 2% cross-reactivity with recombinant mouse IL-7 R alpha is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
CD127 (Interleukin-7 receptor alpha, IL-7Rα) is a glycoprotein involved in the regulation of lymphopoiesis. The response of cells to CD127 depends on the presence of the IL7R complex, which is an alpha/gamma chain heterodimer.
The gamma(c) chain, shared with the IL-2 receptor, mainly activates signal transduction, while the alpha chain determines specific signaling through cytoplasmic molecules.
CD127 promotes the proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells.
Dysfunction of CD127 is associated with severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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