Thermo Fisher Scientific EBI3 Monoclonal Antibody (15k8D10)

Applications

Product Specifications

Product Specific Information

The human Interleukin-35 (IL-35) protein is a dimeric complex consisting of the IL-12a/p35 subunit (NP_000873.2) and the human EBI3 (NP_005746) protein.
This antibody clone (15K8D10) is specific to the EBI3 subunit of the target protein.
Endotoxin level: < 0.06 EU/µg.

Target Information

EBI3 (Epstein-Barr virus Induced-3) is a secreted glycoprotein belonging to the hematopoietin receptor family.
It plays a key regulatory role in Th2-type immune responses and Th2-mediated tissue inflammation, potentially through iNKT cell regulation.
EBI3 forms heterodimers with p28 and p35 subunits to create IL-27 and IL-35, respectively. IL-27, produced by activated antigen-presenting cells upon TLR ligation, negatively regulates Th17 cell differentiation.
EBI3 expression in dendritic cells is transcriptionally regulated by TLR signaling via MyD88 and NF-κB during innate immune responses.
EBI3 signaling inhibits delayed-type hypersensitivity by suppressing IL-17 and inducing IL-10 production.
It may also regulate tumor metastasis through lung CD8+ T cells, and EBI3 deficiency is associated with reduced Th2 cytokine production and decreased allergic airway inflammation in asthma.
Targeted deletion of EBI3 has been shown to protect mice from lung metastasis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.