Thermo Fisher Scientific ITGA2 Monoclonal Antibody (HAS-3)
인간 반응성 ITGA2(CD49b) 단클론 항체로 다양한 면역분석(IHC, ICC, Flow, IP)에 사용 가능. 마우스 IgG2a 아이소타입, Protein A 정제, 액상 형태. Laminin, Collagen, Fibronectin 결합 연구 및 면역세포 표지에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:10–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:10–1:1,000 |
| Immunoprecipitation (IP) | 1:10–1:500 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HAS-3 |
| Immunogen | Whole human keratinocytes |
| Target Family | CD49b (Integrin alpha 2) |
| UniProt ID | P17301-1 |
| Antigen Range | 1–1181 |
| Antigen Length | 1181 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1016768 |
Target Information
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a 150 kD glycoprotein that complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (Integrin alpha 2 beta 1, or GPIa/IIa).
VLA-2 acts as an extracellular receptor for laminin, collagen, and fibronectin, triggering intracellular signaling upon ligand binding.
It plays roles in VEGF-induced angiogenesis, adhesion, and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, epithelial cells, and subsets of T and B cells, including CD4+ Tr1 regulatory T cells co-expressing LAG-3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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