Thermo Fisher Scientific CD171 Monoclonal Antibody (UJ127.11)
CD171(L1CAM) 단백질을 인식하는 UJ127.11 클론의 Mouse IgG1 단일클론 항체. WB, IHC, ICC, Flow 등 다양한 응용에 적합. 신경계 발달 연구 및 L1CAM 관련 질환 연구용. 단백질 A/G 정제, PBS buffer, 1 mg/mL 농도.
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Thermo Fisher Scientific CD171 Monoclonal Antibody (UJ127.11)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent |
| Immunocytochemistry (ICC/IF) | 2–5 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg/mL |
| ELISA | 1:100–1:2,000 |
| Immunoprecipitation (IP) | 1:10–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UJ127.11 |
| Immunogen | Homogenous suspension of 16-week human fetal brain |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1016758 |
Target Information
L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family. Its ectodomain contains multiple immunoglobulin-like and fibronectin type III domains, connected via a transmembrane sequence to a conserved cytoplasmic domain. This molecule is crucial for nervous system development, including neuronal migration and differentiation. Mutations in L1CAM cause X-linked neurological disorders collectively referred to as CRASH syndrome (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, and hydrocephalus). Alternative splicing of neuron-specific exons is functionally significant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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