Thermo Fisher Scientific Phospho-Cytokeratin 18 (Ser51) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of Cytokeratin 18 only when phosphorylated at Ser51.

Target Information

Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins and exists in combination with cytokeratin 8. It is expressed in tissues from the gastrointestinal, respiratory, and urogenital tracts, as well as in endocrine, exocrine, and mesothelial cells. Cytokeratin 18 is mainly found in non-squamous epithelia and is present in most adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas. Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been associated with cryptogenic cirrhosis. Two transcript variants encoding the same protein have been identified. Expression patterns of cytokeratin subtypes are increasingly used to distinguish epithelial malignancies. Cytokeratin antibodies are valuable tools for tumor differential diagnosis using immunohistochemistry, cytopathology, and flow cytometry assays.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.