Thermo Fisher Scientific Phospho-Chk2 (Ser33, Ser35) Polyclonal Antibody
Human, Mouse, Rat 반응성의 Rabbit Polyclonal 항체로, CHK2 단백질의 Ser33 및 Ser35 인산화 상태를 특이적으로 검출. Western blot, IHC, ICC/IF에 적합. DNA 손상 반응 및 종양 억제 관련 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CHEK2 (Accession O96017), corresponding to amino acid residues around phosphorylated Ser33 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899197 |
Product Specific Information
Antibody detects endogenous levels of CHK2 only when phosphorylated at Ser33+Ser35.
Target Information
CHEK2 (CHK2) is a serine/threonine kinase involved in the DNA damage checkpoint pathway. Mutations in CHK2 are linked to various cancers. CHK2 activation by DNA damage leads to phosphorylation of cell cycle regulators, including tumor suppressor proteins. It can phosphorylate BRCA1, aiding survival after DNA damage. CHK2 mutations are associated with Li-Fraumeni syndrome, sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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