Thermo Fisher Scientific ARTS1 (ERAP1) Monoclonal Antibody (OTI6E3)
ERAP1 단백질을 표적으로 하는 Thermo Fisher Scientific의 ARTS1 (ERAP1) 단일클론 항체. 인간, 마우스, 랫트 반응성. Western blot에 적합하며, 고순도 친화 크로마토그래피 정제. 동결건조 형태로 안정적 보관 가능.
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Thermo Fisher Scientific ARTS1 (ERAP1) Monoclonal Antibody (OTI6E3)
Applications
- Western Blot (WB)
Tested Dilution: 1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6E3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 529-941 of human ERAP1 (NP_001035548) produced in E.coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
To use this carrier-free antibody for conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a 120 kDa protein localized in the ER lumen. It removes NH₂-terminal residues from antigenic precursors for MHC class I peptide presentation. ERAP1 trims peptides of 9 amino acids or more and is induced by interferon-gamma.
The human ERAP1 gene maps to chromosome 5q15 and is also known as:
- A-LAP (Adipocyte-derived leucine aminopeptidase)
- PILS-AP (Puromycin-insensitive leucine-specific aminopeptidase)
- ARTS-1 (Aminopeptidase regulator of TNFR1 shedding)
A-LAP may regulate blood pressure via angiotensin II inactivation. PILS-AP plays a role in angiogenesis, and ARTS-1 promotes TNFR1 shedding. Further studies are needed to fully elucidate ERAP1 functions.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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