Thermo Fisher Scientific ARTS1 (ERAP1) Monoclonal Antibody (OTI5D4)

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a 120 kDa protein localized in the ER lumen.
It removes N-terminal residues from antigenic precursors for MHC class I peptide presentation.
Peptides presented by MHC class I are typically 8–11 residues long, and ERAP1 trims peptides of 9 or more amino acids.
ERAP1 expression is induced by interferon-gamma, and the human gene maps to chromosome 5q15.

ERAP1 is also known as:

• Adipocyte-derived leucine aminopeptidase (A-LAP)
• Puromycin-insensitive leucine-specific aminopeptidase (PILS-AP)
• Aminopeptidase regulator of TNFR1 shedding (ARTS-1)

A-LAP inactivates bioactive peptides such as angiotensin II, potentially regulating blood pressure.
PILS-AP contributes to angiogenesis by modulating endothelial cell proliferation and migration.
ARTS-1 acts as a TNFR1-binding protein that promotes TNFR1 shedding.
Further research is required to fully elucidate the functions of ERAP1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.