Thermo Fisher Scientific DCC Monoclonal Antibody (OTI5D10), TrueMAB
DCC 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot에 적합. 인간 DCC 단백질 전체 길이 항원으로 제작됨. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보관. 종양 억제 관련 연구에 활용 가능.
- 판매단위
- pk
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D10 |
| Immunogen | Full-length human recombinant protein of human DCC produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand.
The cytoplasmic tail interacts with tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction.
The protein partially localizes to lipid rafts and induces apoptosis in the absence of ligand.
It functions as a tumor suppressor and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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