Thermo Fisher Scientific Catenin, beta (CTNNB1) Recombinant Rabbit Monoclonal Antibody (CTNNB1/7044R)
Recombinant rabbit monoclonal antibody targeting human beta-catenin (CTNNB1). Suitable for IHC (Paraffin) and IHC (PFA fixed) applications. High purity Protein A purified, liquid form, 200 µg/mL concentration. For research use only.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CTNNB1/7044R |
| Immunogen | Recombinant full-length human beta-catenin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and epithelial layer maintenance. It interacts with E-cadherin and alpha-catenin to anchor the E-cadherin complex to the actin cytoskeleton. Beta-catenin also participates in signaling pathways such as Wnt/Wingless and interacts with proteins like adenomatous polyposis coli. Its dysregulation is associated with various cancers, including colorectal, ovarian, breast, and liver tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, promoting expression of genes like cyclin D and c-myc that drive cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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