Thermo Fisher Scientific Catenin, beta (CTNNB1) Recombinant Rabbit Monoclonal Antibody (CTNNB1/7044R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• 1–2 µg/mL

Product Specifications

Target Information

Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and epithelial layer maintenance. It interacts with E-cadherin and alpha-catenin to anchor the E-cadherin complex to the actin cytoskeleton. Beta-catenin also participates in signaling pathways such as Wnt/Wingless and interacts with proteins like adenomatous polyposis coli. Its dysregulation is associated with various cancers, including colorectal, ovarian, breast, and liver tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, promoting expression of genes like cyclin D and c-myc that drive cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.