Thermo Fisher Scientific Leptin Receptor Recombinant Rabbit Monoclonal Antibody (JA73-01)
Leptin Receptor에 특이적인 재조합 토끼 단클론 항체로, 높은 특이성과 민감도를 제공합니다. WB, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합합니다. 1 mg/mL 농도의 액상 형태이며, 안정적인 단백질 A 정제 및 glycerol 기반 저장 버퍼를 포함합니다.
- 판매단위
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Thermo Fisher Scientific Leptin Receptor Recombinant Rabbit Monoclonal Antibody (JA73-01)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 | - |
| Flow Cytometry (Flow) | 1:50–1:100 | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JA73-01 |
| Immunogen | Synthetic peptide within Human Leptin Receptor (aa 1041–1090) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% Sodium Azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809962 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to rabbit immune repertoire
Target Information
The leptin (OB-R) receptor belongs to the cytokine receptor superfamily and plays a key role in body weight homeostasis and energy balance. Activation of OB-R by leptin initiates downstream signaling via the JAK/STAT pathway.
Leptin induces homo-dimerization of OB-R domains, triggering intracellular signaling.
Multiple OB-R isoforms exist, differing in signaling capabilities. The OB-R long form is expressed in the choroid plexus and hypothalamus, central to satiety and energy expenditure.
Mutations in OB-R (db) or leptin (ob) genes cause early-onset obesity with metabolic abnormalities such as hyperinsulinemia, insulin resistance, and altered CNS activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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