Thermo Fisher Scientific Humanin Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues L(9) L L L T S E I D L P V K R R A(24) of human Humanin. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Humanin,uniProtId:Q8IVG9-1,ncbiNodeId:9606,antigenRange:9-24|10-24,antigenLength:24,antigenImageFileName:PA1-4358_Humanin_Q8IVG9-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4358_Humanin_Q8IVG9-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_559548

Product Specific Information

PA1-4358 detects Humanin from human samples.

PA1-4358 has been successfully used in Western blot procedures.

The PA1-4358 immunogen is a synthetic peptide corresponding to residues L(9) L L L T S E I D L P V K R R A(24) of human Humanin.

Target Information

Humanin is a novel 24 A. A polypeptide identified in Alzheimers disease-affected brain. It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor. It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimers disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids. It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity. It activates JAK/STAT signaling pathway and is regulated by TRIM11. It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells. Humanin is also expressed in colon and testis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.