Thermo Fisher Scientific AMID Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide: V(170) T L I H S Q V A L A D K E L L(185) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:AMID,uniProtId:Q9BRQ8-1,ncbiNodeId:9606,antigenRange:170-185,antigenLength:373,antigenImageFileName:PA1-4345_AMID_Q9BRQ8-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4345_AMID_Q9BRQ8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2169232

Product Specific Information

PA1-4345 detects the human PRG3 protein in human samples.

PA1-4345 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~41 kDa protein representing PRG3 in human heart lysate.

The PA1-4345 immunizing peptide corresponds to amino acid residues residues 170-185 of the 41 kDa human PRG3 protein.

Target Information

The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. PRG3 (p53-responsive gene 3), is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells. PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF. Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis. The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.