Thermo Fisher Scientific MEK1 C-Term Monoclonal Antibody (13B6.G12)
MEK1 단백질의 C-말단에 특이적인 마우스 모노클로날 항체. Western blot과 ELISA에 적합하며 인간, 마우스, 랫트에 반응. 비결합형 형태로 제공되며 Protein A로 정제됨. -20°C에서 보관하며 반복 동결/해동은 피해야 함.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| ELISA | 1:40,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 13B6.G12 |
| Immunogen | Synthetic peptide corresponding to amino acid residues near the C-terminus of MEK1 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.02 M potassium phosphate, pH 7.2, with 0.15 M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
- Biotin
- DyLight 680
- DyLight 800
- FITC
- HRP
- Custom conjugation available upon request
Product Specific Information
Store vial at -20°C prior to opening. This product is stable at 4°C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
This antibody reacts specifically with human MEK1. Cross-reactivity is expected with human, mouse, and rat based on sequence identity of the peptide immunogen. It does not react with the MEK2 isoform.
Target Information
MAP2K1 (MEK1) kinase is a dual-specificity protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by various growth factors, cytokines, membrane depolarization, and calcium influx. MEK1 is activated by phosphorylation of serine residues 218 and 222 by Raf1 and is involved in stress response, apoptosis, and proliferative signaling. Mutations in MAP2K1 can lead to cardiofaciocutaneous syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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