Thermo Fisher Scientific P-Glycoprotein Recombinant Rabbit Monoclonal Antibody (SN06-42)
P-glycoprotein을 표적하는 재조합 토끼 단클론 항체로, WB, IHC, ICC 등 다양한 응용 가능. 높은 특이성과 재현성을 제공하며, HEK293 세포 발현 시스템을 사용. 단백질 A 정제, 1 mg/mL 농도, 장기 보관 시 -20°C 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN06-42 |
| Immunogen | Recombinant protein within Human P-glycoprotein 1 aa 373–730 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809567 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
The membrane-associated protein encoded by this gene belongs to the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across cellular membranes and are divided into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MDR/TAP subfamily, involved in multidrug resistance. It functions as an ATP-dependent efflux pump for xenobiotic compounds, reducing drug accumulation in resistant cells and contributing to anticancer drug resistance. It also acts as a transporter in the blood-brain barrier.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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