Thermo Fisher Scientific Human Alpha-1-Antitrypsin Polyclonal Antibody, Biotin

Applications and Tested Dilution

Product Specifications

Product Specific Information

Goats were immunized with purified human alpha-1-antitrypsin of serum or plasma origin.
The antibody was isolated by affinity chromatography using antigen coupled to agarose beads.
Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.

Target Information

Alpha-1-Antitrypsin (Alpha-1-AT) is synthesized in the liver and functions as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin.
In the absence of alpha-1-AT, these enzymes may digest pulmonary parenchyma, leading to tissue damage.
Deficiency of alpha-1-AT is associated with chronic obstructive lung disease (emphysema) and, less frequently, hepatic cirrhosis in infants and respiratory distress in newborns.
Elevated alpha-1-AT levels occur as an acute phase response to tissue necrosis and inflammation, and are observed in conditions such as rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.