Thermo Fisher Scientific Human Alpha-1-Antitrypsin Polyclonal Antibody, Biotin
Human Alpha-1-Antitrypsin을 인식하는 Biotin 결합 Polyclonal Antibody로, Western Blot 및 ELISA에 적합. Goat에서 유래한 IgG 항체이며, 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 농도의 액상 형태로, PBS 완충액에 0.2% BSA 및 0.09% sodium azide 포함. 연구용 전용 제품.
- 카탈로그번호
- A80122B
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:10,000 - 1:100,000 |
| ELISA | 1:10,000 - 1:100,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 6.8–7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Goats were immunized with purified human alpha-1-antitrypsin of serum or plasma origin.
The antibody was isolated by affinity chromatography using antigen coupled to agarose beads.
Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.
Target Information
Alpha-1-Antitrypsin (Alpha-1-AT) is synthesized in the liver and functions as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin.
In the absence of alpha-1-AT, these enzymes may digest pulmonary parenchyma, leading to tissue damage.
Deficiency of alpha-1-AT is associated with chronic obstructive lung disease (emphysema) and, less frequently, hepatic cirrhosis in infants and respiratory distress in newborns.
Elevated alpha-1-AT levels occur as an acute phase response to tissue necrosis and inflammation, and are observed in conditions such as rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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