Thermo Fisher Scientific Human Alpha-1-Antitrypsin Polyclonal Antibody, FITC

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200 - 1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:200 - 1:2,000

Product Specifications

Product Specific Information

Goats were immunized with purified human alpha-1-antitrypsin of serum or plasma origin.
The antibody was isolated by affinity chromatography using antigen coupled to agarose beads.
Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.

Target Information

Alpha-1-AT is synthesized in the liver and acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung.
Deficiency of alpha-1-AT is associated with chronic obstructive lung disease (emphysema) and, less frequently, hepatic cirrhosis in infants and respiratory distress of the newborn.
Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation.
Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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