Thermo Fisher Scientific ITFG2 Monoclonal Antibody (OTI 2H5), TrueMAB

Thermo Fisher Scientific ITFG2 Monoclonal Antibody (OTI 2H5), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The ITFG2 protein is part of the KICSTOR complex, functioning in the amino acid-sensing branch of the TORC1 signaling pathway. It recruits the GATOR1 complex to lysosomal membranes, enabling interaction with GATOR2 and RAG GTPases. ITFG2 acts upstream of RAG GTPases and is essential for negative regulation of mTORC1 signaling in the absence of amino acids. Without the KICSTOR complex, mTORC1 remains constitutively localized to lysosomes and activated. The complex may also be involved in the regulation of mTORC1 by glucose.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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