Thermo Fisher Scientific CD249 (BP-1) Monoclonal Antibody (6C3), eBioscience
Mouse BP-1 (CD249) 단백질을 인식하는 Rat IgG2a 단클론 항체로, Flow Cytometry, IHC, IP 등에 사용 가능. Bone marrow stromal 및 pre-B cell 표지용으로 적합. 고순도(>90%) 및 0.5 mg/mL 농도로 제공.
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Thermo Fisher Scientific CD249 (BP-1) Monoclonal Antibody (6C3), eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | Assay-Dependent | View 1 publication |
| Flow Cytometry (Flow) | 1 µg/test | View 9 publications |
| Immunoprecipitation (IP) | Assay-Dependent | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6C3 |
| Conjugate | Unconjugated |
| Available Formats | APC, Biotin, FITC, PE, PerCP-eFluor 710 |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2865169 |
Product Specific Information
The 6C3 monoclonal antibody reacts with mouse BP-1, also known as Ly-51 and 6C3 antigen.
BP-1 is a 140 kDa type II transmembrane protein present on the surface as a disulfide-linked homodimer.
It functions as an enzyme with aminopeptidase A (APA) activity and is expressed by bone marrow stromal cells, thymic cortical epithelial cells, and early-stage mouse B cells (pre-B cells).
BP-1 expression on pre-B cells can be upregulated in the presence of IL-7.
Applications Reported:
Flow cytometric analysis, immunoprecipitation, and immunohistochemical staining.
Applications Tested:
Tested by flow cytometric analysis of mouse bone marrow cells. Recommended ≤1 µg per test (100 µL final volume).
Cell number range: 10⁵–10⁸ cells/test.
Careful titration recommended for optimal assay performance.
Purity: Greater than 90%, as determined by SDS-PAGE.
Aggregation: Less than 10%, as determined by HPLC.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD249 is involved in the catabolic pathway of the renin-angiotensin system and may regulate growth and differentiation of early B-lineage cells.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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