Thermo Fisher Scientific GnRH-Receptor/LH-RH Receptor Monoclonal Antibody (A9E4)
GnRH 수용체를 인식하는 단클론 항체로, Western blot 분석에 적합합니다. 인간 시료에 반응하며 돼지 및 토끼에서도 예측 반응합니다. Protein A/G로 정제된 액상 항체이며, PBS 완충액에 0.05% BSA와 sodium azide가 포함되어 있습니다. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A9E4 |
| Immunogen | A synthetic peptide aa 1–29 (MANSASPEQNQHCSAINNSIPLMQGNLPY) from the N-terminal of human GnRH receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C, do not freeze |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Predicted to react with Pig, Rabbit
Target Information
This gene encodes the receptor for type 1 gonadotropin-releasing hormone (GnRH).
The receptor belongs to the seven-transmembrane, G-protein coupled receptor (GPCR) family.
It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate.
Upon binding GnRH, the receptor activates a phosphatidylinositol-calcium second messenger system, leading to the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH).
Defects in this gene are associated with hypogonadotropic hypogonadism (HH).
Alternative splicing results in multiple transcript variants encoding different isoforms.
More than 18 transcription initiation sites and multiple polyadenylation signals have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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