Thermo Fisher Scientific CD282 (TLR2) Monoclonal Antibody (TL2.1), Biotin, eBioscience
인간 TLR2에 특이적인 TL2.1 단클론 항체로, Biotin으로 표지되어 있습니다. Flow Cytometry 분석에 최적화되어 있으며, 면역반응 및 병원체 인식 연구에 활용됩니다. 0.5 mg/mL 농도의 액상 형태로 제공되며, 4°C 암소 보관 권장.
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Thermo Fisher Scientific CD282 (TLR2) Monoclonal Antibody (TL2.1), Biotin, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 2 publications |
| Immunocytochemistry (ICC/IF) | - | View 2 publications |
| Flow Cytometry (Flow) | 1 µg/test | View 11 publications |
| Functional Assay (Functional) | - | View 5 publications |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Recommended Isotype Control | Mouse IgG2a kappa Isotype Control (eBM2a), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TL2.1 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_466990 |
| Filtration | 0.2 µm post-manufacturing filtered |
Product Specific Information
The TL2.1 monoclonal antibody reacts with human Toll-like receptor 2 (TLR2). TLR2 is a type I transmembrane protein involved in innate immunity and inflammation, expressed by peripheral blood monocytes. TL2.1 is a blocking antibody used to study TLR2’s role in microbial lipoprotein/lipopeptide-induced cytokine production. It immunoprecipitates human TLR2 (~90 kDa) from PBMC and HMEC.
Applications Reported: TL2.1 antibody has been reported for use in flow cytometric analysis.
Applications Tested: Tested by flow cytometric analysis of normal human peripheral blood cells. Recommended ≤1 µg/test in 100 µL final volume. Optimal performance should be determined empirically.
Target Information
TLR2 is part of the Toll-like receptor family, crucial for pathogen recognition and activation of innate immunity. It forms heterodimers with TLR1 or TLR6 to recognize bacterial and mycoplasma lipoproteins. TLR2 is highly expressed in peripheral blood leukocytes and mediates host response to Gram-positive bacteria and yeast via NF-kappaB activation.
Expression is highest in CD14+ monocytes, followed by granulocytes, B-cells, and T-cells. Cytokines such as LPS, GM-CSF, IL-1, and IL-10 upregulate TLR2, while IL-4, IFN-gamma, and TNF downregulate its expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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