Thermo Fisher Scientific Blood Group Antigen H (O) Type 1 Monoclonal Antibody (17-206), Biotin, eBioscience
인체 혈액형 항원 H(O) Type 1을 인식하는 단클론 항체로, IHC(P), IHC(F), ICC/IF 등 다양한 면역염색에 사용됩니다. Biotin 결합형으로 고감도 검출이 가능하며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | Assay-Dependent | - |
| Functional Assay | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG3 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 17-206 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11218500 |
| Filtration | 0.2 µm post-manufacturing filtered |
Product Specific Information
Description:
Monoclonal antibody 17-206 recognizes the human blood group antigen H (O) type 1, primarily found in epithelial and secretory cells. The H antigen serves as a precursor to A and B antigens, modified by specific glycosyltransferases. Depending on ABO blood type, the H antigen may be converted into A, B, both, or remain unconverted (O antigen).
Evidence suggests that H antigen expression is reduced in tumor cells, correlating with disease progression, indicating potential roles in cell proliferation, adhesion, and angiogenesis. The 17-206 antibody does not recognize blood group antigen H (O) type 2.
Applications Reported:
- Immunohistochemistry on frozen and formalin-fixed paraffin-embedded tissues
- Immunocytochemistry
Applications Tested:
- Tested by IHC on human tissues using high or low pH antigen retrieval at ≤10 µg/mL.
- Recommended to titrate for optimal performance.
Target Information
The H antigen is a precursor to ABO blood group antigens. Individuals with the Bombay phenotype (hh) lack H antigen on RBCs and therefore also lack A and B antigens. They produce isoantibodies to H, A, and B antigens, making transfusion compatibility limited to hh donors.
H antigen production is controlled by the H locus on chromosome 19, encoding a fucosyltransferase responsible for H antigen synthesis. The antigen is a carbohydrate sequence linked mainly to proteins, with a minor fraction attached to ceramide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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