Thermo Fisher Scientific TERT Polyclonal Antibody
TERT 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western Blot과 IHC에 적합. Hydra TERT 합성 펩타이드로 면역화된 항원 사용. Lyophilized 형태, whole serum buffer, 무보존제. 연구용으로 세포 노화 및 텔로머라제 관련 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Miscellaneous PubMed (Misc)
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cnidarian |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 850–900 of hydra TERT conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TERT
Target Information
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG.
The enzyme consists of a protein component with reverse transcriptase activity (encoded by the TERT gene) and an RNA component that serves as a template for telomere repeat synthesis.
Telomerase expression is normally repressed in postnatal somatic cells, leading to progressive telomere shortening and cellular senescence.
Deregulation of telomerase expression may contribute to oncogenesis.
Studies in mouse suggest telomerase also participates in chromosomal repair, as de novo telomere synthesis may occur at double-stranded breaks.
Alternative splicing variants encoding different isoforms of TERT have been identified and may regulate telomerase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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